Everything about Guanidinium Chloride totally explained
Guanidinium chloride (GndCl) is one of the strongest
denaturants used in physiochemical studies of
protein folding. In 6
M GndCl all
proteins with well ordered structure lose it, and most of them become randomly coiled, for example they don't contain any residual structure.
Historical Survey
Petrunkin and Petrunkin (1927, 1928) appear to be the first who studied the binding of GndCl to
gelatin and a mixture of thermally denatured protein from brain extract. Greenstein (1938, 1939), however, appears to be the first to discover the high denaturing action of guanidinium
halides and thiocynates in following the liberation of
sulfhydryl groups in
ovalbumin and few other proteins as a function of salt concentration.
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